As the global population ages, it is increasingly vital to develop intervention strategies that address the aging process itself, rather than focusing exclusively on organ-specific or disease-oriented treatments. The geroscience hypothesis, which posits that delaying the aging process could prevent the onset of various diseases, is gaining prominence due to advancements in aging biomarkers. These advancements are fueled by improvements in measurement techniques (such as omics) and analytical technologies (including bioinformatics).
In their editorial, researchers Takuji Kawamura, Radak Zsolt, Mitsuru Higuchi, and Kumpei Tanisawa from the Faculty of Sport Sciences at Waseda University and the Research Center for Molecular Exercise Science at the Hungarian University of Sports Science, highlight the critical need to explore the connection between cardiorespiratory fitness (CRF) and the DNA methylation (DNAm) aging clock.
Their objective is to establish reference values for fitness that could contribute to delaying the aging process. They also discuss their recent study, "Associations between Cardiorespiratory Fitness and Lifestyle-Related Factors with DNA Methylation-Based Aging Clocks in Older Men: WASEDA'S Health Study."
"Our research supports the geroscience hypothesis, demonstrating that active lifestyle choices can influence quantifiable molecular biomarkers that reflect biological aging," the authors assert.
More information: Takuji Kawamura et al, Physical fitness and lifestyles associated with biological aging, Aging (2024). DOI: 10.18632/aging.206031
0 Comments